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KMID : 0941819910010010015
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Korean Journal of Clinical Pharmacy
1991 Volume.1 No. 1 p.15 ~ p.21
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Bioavailability of Commercially Available Furosemide Tablet
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Lee Jin-Hwan
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Abstract
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This study was attempted to investigate the dissolution rate and bioavailability of commercially available furosemide preparations. A. B. and C. The dissolution test was conducted in an artificial gastric juice using the basket method. and furosemide (40 mg) was administered orally to 8 normal volunteers by cross-over design. The results were as follows: the AUC and dissolution rate in 100 min (D_{100;min}) were higher in order of preparations. A > C > B. But the peak concentration. time to reach peak concentration (T_{max}), and mean dissolution time (MDT) were in order of preparations. C > A > B. There were significantly linear correlations between the AUC and the D_{100;min}, and between the T_{max} and the MDT. From the results of this experiment. it can be concluded that commercially available preparations bioavailability of furosemide, which may be predicted from the dissolution rate.
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